At first glance, the Vertical Mouse looks all wrong and I instinctively want to tip it back over again -- but I'm a Little Endian. It's supposed to be more ergonomic than the mouse we all currently use, with a shape to "support your hand in a fully upright handshake position which reduces pain and strain from the forearm twisting you get from a normal mouse". No, it doesn't slide sideways when you click. As usual, it's for Windows (although the site does have a link to a shareware Mac driver). Comes in silver and black and has models for both lefties and righties. $80. [GT]
Vertical Mouse [via GetUSB.info]
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These are great and have cleared up the carpel-tunnel syndrome pains I used to have. I have 3 of these...two right-handed and a lefty. Even though I'm right handed, I use the lefty at work to put as little stress on my right wrist. I use the two righties at home on my desktop and laptops.